Peripheral targets of 5-HT1D receptor immunoreactive trigeminal ganglion neurons

Abstract

Objective.- The aim of the current study was to determine the proportion of trigeminal primary afferent neurons that innervate the intracranial vasculature, and other craniofacial tissues, that are also 5 hydroxy triptamine (5-HT)1D receptor immunoreactive. Methods.- Retrograde tracing and immunohistochemistry was used to identify 5-HT1D receptor labeled trigeminal primary afferent neurons that innervate the lacrimal gland (n = 3 animals), nasal mucosa (n = 3 animals), and the intracranial vasculature (middle meningeal artery in the dura [n = 3 animals] and middle cerebral artery [n = 3 animals]). Results.- The percentage of neurons that were 5-HT1D receptor immunoreactive was greater for pr..